Searchable abstracts of presentations at key conferences in endocrinology

ea0090p132 | Pituitary and Neuroendocrinology | ECE2023

Comparative Efficacy and Safety of Osilodrostat Vs Metyrapone for the Treatment of Cushing’s Syndrome – a Matching-Adjusted Indirect Treatment Comparison

Tyas Emma , Hickey Conor , Hemstock Matthew , Binowski Grzegorz , Rios Carl , Schmidt Fabian

Objectives: Endogenous Cushing’s Syndrome (CS) is a rare, chronic condition that results in high morbidity, caused by prolonged exposure to elevated levels of circulating free cortisol levels. Osilodrostat, a newly approved steroidogenesis inhibitor, has been shown to achieve fast and high rates of cortisol normalization, improving manifestations of hypercortisolism in patients with Cushing’s Disease (CD), a form of CS. We evaluated relative complete response (CR) ou...